PAL Physiotherapy provides effective Treatment for Carpal Tunnel Syndrome The symptoms of Carpal Tunnel Syndrome usually develop gradually. Some of the initial symptoms include - Numbness or tingling in the thumb, index and middle fingers (The tingling often comes and goes rather than being persistent) A burning, tingling, or itching numbness in the palm of the hand and thumb, or index and middle fingers Less grip strength as the disorder becomes severe Ache and discomfort in the forearm and sometimes in the upper arm as well Pain in the wrists or hands Loss of manual dexterity Numbness and paresthesias in the median nerve distribution Weakness and atrophy of the thumb muscles Discomfort at night and morning